Clinically Tested Hair Growth Vitamins for Women - Advanced Supplement System - 2 Month Supply Kit

Vitamin A is a fat-soluble vitamin that plays a crucial role in supporting healthy skin and hair. Several studies have shown that vitamin A contributes to women’s hair health by supporting the secretion of sebum, an oily substance that helps to moisturize hair and protect it from getting brittle and breaking off. In addition, vitamin A supports the growth and development of melanocytes and other cells of the hair follicles influencing healthy hair growth and color. It also works as an antioxidant, which means it helps protect hair follicles and cells from oxidative stress caused by free radicals. Please see below reference to relevant scientific studies:

1) Suo L, Sundberg JP, Everts HB. Dietary vitamin A regulates wingless-related MMTV integration site signalling to alter the hair cycle. Exp Biol Med (Maywood). 2015;240(5):618-623.doi:10.1177/1535370214557220
2) Everts HB. Endogenous retinoids in the hair follicle and sebaceous gland. Biochim Biophys Acta. 2012;1821(1):222-229.doi:10.1016/j.bbalip.2011.08.017

Vitamin C, also known as ascorbic acid, promotes hair health by helping with collagen production and aiding in the absorption of iron, both of which are needed for longer and thicker hair, reduction of greying and healthy structure of the hair follicle. Studies have shown that oral vitamin C supplementation can effectively promote significant hair growth in women with temporary hair thinning. It can also reduce the risk of hormone dihydrotestosterone (DHT) becoming too high caused by hormonal imbalances and PCOS. Too much of DHT in women can cause the hair follicles to shrink, resulting in brittle, thin, delicate hair that is more likely to fall out. Please see below reference to relevant scientific studies:

1) Boyera N, Galey I, Bernard BA. Effect of vitamin C and its derivatives on collagen synthesis and cross-linking by normal human fibroblasts. Int J Cosmet Sci. 1998;20(3):151-158. doi:10.1046/j.1467-2494.1998.171747.x
2) Lynch SR, Cook JD. Interaction of vitamin C and iron. Ann N Y Acad Sci. 1980;355:32-44. doi:10.1111/j.1749-6632.1980.tb21325.x
3) Glynis A. A Double-blind, Placebo-controlled Study Evaluating the Efficacy of an Oral Supplement in Women with Self-perceived Thinning Hair. J Clin Aesthet Dermatol. 2012;5(11):28-34
4) Kwack MH, Kim MK, Kim JC, Sung YK. L-ascorbicacid 2-phosphate represses the dihydrotestosterone-induced dickkopf-1expression in human balding dermal papilla cells. Exp Dermatol.2010;19(12):1110-1112. doi:10.1111/j.1600-0625.2010.01143.x

Biotin plays an important role in stimulating keratin production, a protein that forms the structure of hair making the hair strands stronger and less prone to breakage and splitting. Biotin is also essential for maintaining a healthy scalp. It supports the production of fatty acids, which help nourish the scalp and prevent dryness and flakiness. Research shows that biotin deficiency is present in more than 1/3 of women complaining of hair loss. Biotin deficiency may cause a condition called diffuse telogen effluvium (an intense form of hair loss usually visible as losing clumps of hair when showering), as well as seborrheic dermatitis. Please see below reference to relevant scientific studies:

1) Patel DP, Swink SM, Castelo-Soccio L. A Review of the Use of Biotin for Hair Loss. Skin Appendage Disord.2017;3(3):166-169. doi:10.1159/000462981
2) Trüeb RM. Serum Biotin Levels in Women Complaining of Hair Loss. Int J Trichology. 2016;8(2):73-77.doi:10.4103/0974-7753.188040

Folic acid is involved in DNA synthesis and cell division, which are vital processes for the growth and repair of tissues, including hair follicles. Adequate folic acid levels support the healthy growth of hair follicle cells. Folic acid is also important for hair health, as it together with biotin helps to produce keratin, a protein that makes up the structure of hair. Many studies confirms that deficiency in folic acid can lead to hair thinning, weakened hair structure, as well as premature graying of hair (even at the age of 20). Please see below reference to relevant scientific studies:

1) Yousefi M, Namazi MR, Rahimi H, Younespour S,Ehsani AH, Shakoei S. Evaluation of Serum Homocysteine, High-Sensitivity CRP,and RBC Folate in Patients with Alopecia Areata. Indian J Dermatol.2014;59(6):630. doi:10.4103/0019-5154.143567
2) Daulatabad D, Singal A, Grover C, Chhillar N.Prospective Analytical Controlled Study Evaluating Serum Biotin, Vitamin B12,and Folic Acid in Patients with Premature Canities. Int J Trichology.2017;9(1):19-24. doi:10.4103/ijt.ijt_79_16

Vitamin B1, also known as thiamine, plays an essential role in hair growth by converting nutrients from food into energy that the body can use. Thiamine is particularly helpful for maintaining a healthy scalp because it stimulates blood vessels to widen. This improves blood flow and oxygen circulation, which helps transfer key nutrients to the hair follicle for healthy hair growth. Research suggests that thiamine can also improve keratinocytes’ function and stimulate hair follicles production. Please see below reference to relevant scientific studies:

1) Arora S, Lidor A, Abularrage CJ, et al. Thiamine (vitamin B1) improves endothelium-dependent vasodilatation in the presence of hyperglycemia. Ann Vasc Surg. 2006;20(5):653-658. doi:10.1007/s10016-006-9055-6
2) Hengl T, Herfert J, Soliman A, Schlinzig K,Trüeb RM, Abts HF. Cystine-thiamin-containing hair-growth formulation modulatesthe response to UV radiation in an in vitro model for growth-limiting conditions of human keratinocytes. J Photochem Photobiol B. 2018;189:318-325.doi:10.1016/j.jphotobiol.2018.09.005

Vitamin B2 also known as riboflavin converts fats, carbs and proteins to produce the cellular energy needed by the entire body for its own maintenance, including hair follicles. Deficits in riboflavin intake, can, therefore, lead to hair loss, among other conditions. Please see below reference to relevant scientific studies:

1) Mahabadi N, Bhusal A, Banks SW. Riboflavin Deficiency. [Updated 2022 Jul 18]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-.

Vitamin B3 or niacin improves blood circulation and brings oxygen to the hair follicles, which results in hair development. Nutrient-rich blood is also critical to maintaining the moisture balance within hair cells. When blood flow is restricted, scalp dryness and damaged hair can result, as well as excessively dry skin throughout the body, resulting in skin disorders. Studies have shown that niacin also works as an antioxidant by stimulating glutathione antioxidant function and can protect scalp cells from oxidative stress caused by stressors in the environment such as UV-damage and pollution. Please see below reference to relevant scientific studies:

1) Sahebkar A. Effect of niacin on endothelial function: a systematic review and meta-analysis of randomized controlled trials. Vasc Med. 2014;19(1):54-66. doi:10.1177/1358863X13515766
2) Choi YH, Shin JY, Kim J, Kang NG, Lee S.Niacinamide Down-Regulates the Expression of DKK-1 and Protects Cells from Oxidative Stress in Cultured Human Dermal Papilla Cells. Clin Cosmet InvestigDermatol. 2021;14:1519-1528. Published 2021 Oct 18. doi:10.2147/CCID.S334145

Vitamin B12, also known as cobalamin, is involved in the production of red blood cells, which carry oxygen and nutrients to the scalp and hair follicles. Adequate oxygen and nutrient supply are crucial for optimal hair growth and maintenance. Vitamin B12 also supports the production of DNA and new cells, including those in the hair follicles, promoting healthy hair growth. Studies shown that deficiency in vitamin B12 can lead to hair loss, weakened hair structure, as well as premature greying of hair, and that supplementation is an effective way to improve hair health. Please see below reference to relevant scientific studies:

1) Durusoy C, Ozenli Y, Adiguzel A, et al. The role of psychological factors and serum zinc, folate and vitamin B12 levels in the aetiology of trichodynia: a case-control study. Clin Exp Dermatol. 2009;34(7):789-792. doi:10.1111/j.1365-2230.2008.03165.x
2) Daulatabad D, Singal A, Grover C, Chhillar N.Prospective Analytical Controlled Study Evaluating Serum Biotin, Vitamin B12,and Folic Acid in Patients with Premature Canities. Int J Trichology.2017;9(1):19-24. doi:10.4103/ijt.ijt_79_16

Vitamin B5 also known as pantothenic acid helps convert nutrients from the foods we consume into energy, providing support for the growth and maintenance of hair follicles. It also acts as a natural humectant, attracting and retaining moisture in the hair, which can contribute to healthier-looking hair. Vitamin B5 supports the strength and flexibility of hair strands by improving the structure and integrity of the hair shaft. Research shows that when used together with zinc it can improve hair thickness and reduce the risk of hair loss. Please see below reference to relevant scientific studies:

1) Siavash M, Tavakoli F, Mokhtari F. Comparing the Effects of Zinc Sulfate, Calcium Pantothenate, Their Combination and Minoxidil Solution Regimens on Controlling Hair Loss in Women: A Randomized Controlled Trial. J Res Pharm Pract. 2017;6(2):89-93.doi:10.4103/jrpp.JRPP_17_17
2) Wang Z, Nan W, Si H, Wang S, Zhang H, Li G. Pantothenic acid promotes dermal papilla cell proliferation in hair follicles of American minks via inhibitor of DNA Binding 3/Notch signaling pathway. LifeSci. 2020;252:117667. doi:10.1016/j.lfs.2020.117667

Research suggests that vitamin B6, also known as pyridoxine, may help reduce hair loss by stimulating dermal papilla cells production. Dermal papilla cells play a crucial role in hair follicle development and hair growth regulation. Vitamin B6 also regulates sebum production in the scalp. Sebum is the natural oil produced by the sebaceous glands that moisturizes the scalp and helps keep the hair strands lubricated and healthy. Please see below reference to relevant scientific studies:

1) Liu G, Cheng G, Zhang Y, et al. Pyridoxineregulates hair follicle development via the PI3K/Akt, Wnt and Notch signallingpathways in rex rabbits. Anim Nutr. 2021;7(4):1162-1172.doi:10.1016/j.aninu.2021.09.003
2) D'Agostini F, Fiallo P, Pennisi TM, De FloraS. Chemoprevention of smoke-induced alopecia in mice by oral administration ofL-cystine and vitamin B6. J Dermatol Sci. 2007;46(3):189-198.doi:10.1016/j.jdermsci.2007.02.005

Zinc is necessary for the synthesis of keratin, a protein which helps build and maintain the structure of the hair. Zinc also has anti-inflammatory properties and can help maintain a healthy scalp providing favorable environment for hair growth. Moreover, zinc plays a role in regulating hormones, including those related to hair growth and hair loss. Studies have shown that zinc supplementation can improve hair health in people with zinc deficiency and different types of hair loss. Please see below reference to relevant scientific studies:

1) Park H, Kim CW, Kim SS, Park CW. The therapeutic effect and the changed serum zinc level after zinc supplementation in alopecia areata patients who had a low serum zinc level. Ann Dermatol.2009;21(2):142-146. doi:10.5021/ad.2009.21.2.142
2) Siavash, Mansour et al. “Comparing the Effects of Zinc Sulfate, Calcium Pantothenate, Their Combination and Minoxidil Solution Regimens on Controlling Hair Loss in Women: A Randomized Controlled Trial.” Journal of research in pharmacy practice vol. 6,2 (2017): 89-93. doi:10.4103/jrpp.JRPP_17_17

Selenium is involved in the production of enzymes that protect cells from oxidative stress. Research has shown that deficiency in selenium may lead to increased oxidative damage to hair follicles, potentially contributing to alopecia areata, condition that causes hair loss. Selenium deficiency may also lead to changes in hair texture, making the hair more brittle and prone to breakage. Some individuals with severe selenium deficiency may experience changes in hair color, such as a shift toward lighter shades. Please see below reference to relevant scientific studies:

1) Feizy V, Mortazavi H, Barikbin B, Yousefi M,Ranjbar A, Farshchian M. Serum selenium level in Iranian patients with alopecia areata. J Eur Acad Dermatol Venereol. 2008;22(10):1259-1260.doi:10.1111/j.1468-3083.2008.02612.x

Around 20% of population is magnesium deficient. Scientific evidence suggest that magnesium deficiency can lead to various health problems including hair loss. Magnesium is involved in protein synthesis and DNA repair, processes that are essential for healthy hair growth. A deficiency in magnesium may also lead to hair loss or hair thinning and condition known as alopecia areata. In addition, magnesium has been linked to stress reduction, and stress is known to be a contributing factor in hair loss and premature greying. Adequate magnesium levels may help manage stress and potentially mitigate its impact on hair health. Please see below reference to relevant scientific studies:

1) Tataru A, Nicoara E. Idiopathic diffusealopecias in young women correlated with hypomagnesemia. J Eur Acad DermatolVenereol. 2004;18(3):393-394. doi:10.1111/j.1468-3083.2004.00660.x

While studies on manganese and hair health are scarce, it's worth noting that manganese is needed for collagen and thyroid hormones production which are both essential for hair health.

Research has shown that MSM may have potential benefits for hair health. It is a naturally occurring compound that contains sulfur, which is a vital component of keratin, the protein that makes up hair strands. Adequate sulfur levels may support the growth and strength of hair. MSM can also support collagen production, which is important for maintaining the structure of hair follicles and the scalp. Please see below reference to relevant scientific studies:

1) Muizzuddin N, Benjamin R. Beneficial Effectsof a Sulfur-Containing Supplement on Hair and Nail Condition. A prospective,double-blind study in middle-aged women. Natural Medicine Journal (2020)
2) Guo D, Zhang L, Zhang L, et al. Effect of DietaryMethylsulfonylmethane Supplementation on Growth Performance, Hair Quality,Fecal Microbiota, and Metabolome in Ragdoll Kittens. Front Microbiol.2022;13:838164. Published 2022 Jul 4. doi:10.3389/fmicb.2022.838164

Curcumin, the active ingredient in turmeric, is a potent anti-inflammatory and antioxidant compound. Inflammation and oxidative stress can play a role in hair loss and scalp conditions. Studies have shown that by reducing inflammation and oxidative stress, curcumin may help create a more favourable environment for hair growth. Findings suggest that it can also help regulate hormone dihydrotestosterone (DHT) levels, preventing it from becoming too high due to hormonal imbalances. Too much of DHT in women can cause the hair follicles to shrink, resulting in brittle, thin, delicate hair that is more likely to fall out. Please see below reference to relevant scientific studies:

1) Pumthong G, Asawanonda P, Varothai S, et al.Curcuma aeruginosa, a novel botanically derived 5α-reductase inhibitor in the treatment of male-pattern baldness: a multicenter, randomized, double-blind, placebo-controlled study. J Dermatolog Treat. 2012;23(5):385-392.doi:10.3109/09546634.2011.568470
2) Barbalho SM, de Sousa Gonzaga HF, de Souza GA, de Alvares Goulart R, de Sousa Gonzaga ML, de Alvarez Rezende B. Dermatological effects of Curcuma species: a systematic review. Clin Exp Dermatol. 2021;46(5):825-833. doi:10.1111/ced.14584
3) Yang Y, Wang P, Gong Y, et al. Curcumin-zinc framework encapsulated microneedle patch for promoting hair growth. Theranostics. 2023;13(11):3675-3688. Published 2023 Jun 26. doi:10.7150/thno.84118

Cuscutae Chinensis, or Chinese Dodder, is an herb that has been traditionally used in Chinese medicine for thousands of years to promote hair growth, prevent hair loss, and maintain overall hair health. Studies have shown that Cuscutae Chinensis extract can stimulate dormant hair follicles and speed-up new hair growth, nourish the hair follicles and scalp, providing nutrients essential for hair growth initiation, strengthen the hair shafts and improve overall hair texture and thickness. Please see below reference to relevant scientific studies:

1) Patel S, Sharma V, Chauhan NS, Dixit VK. A study on the extracts of Cuscuta reflexa Roxb. in treatment of alopecia. Daru. 2014;22(1):7. Published 2014 Jan 6. doi:10.1186/2008-2231-22-7
2) Roy RK, Thakur M, Dixit VK. Development and evaluation of polyherbal formulation for hair growth-promoting activity. J Cosmet Dermatol. 2007;6(2):108-112. doi:10.1111/j.1473-2165.2007.00305.x

Fallopia Multiflora, also known as Fo-Ti or He Shou Wu, is an herb commonly used in traditional Chinese medicine for various health purposes, including its potential to promote hair growth, prevent hair loss, and restore hair color. Studies have shown that Fallopia Multiflora may help restore natural hair color, especially in cases of premature graying and stimulate hair growth by regulating the effects of certain cytokines such as fibroblast growth factor 7, which is a small signalling protein involved in the hair growth. Please see below reference to relevant scientific studies:

1) Li Y, Han M, Lin P, He Y, Yu J, Zhao R. HairGrowth Promotion Activity and Its Mechanism of Polygonum multiflorum. EvidBased Complement Alternat Med. 2015;2015:517901. doi:10.1155/2015/517901
2) Thang ND, Diep PN, Lien PT, Lien LT. Polygonum multiflorum root extract as a potential candidate for treatment of early graying hair. J Adv Pharm Technol Res. 2017;8(1):8-13. doi:10.4103/2231-4040.197332

Saw palmetto is an herbal supplement derived from the fruit of the Serenoa repens plant which can benefit hair health by regulating dihydrotestosterone (DHT) levels, a hormone that plays a role in hair loss. DHT is a byproduct of testosterone, and in some individuals, it can contribute to hair loss by shrinking hair follicles and shortening the hair growth cycle. This condition, known as androgenetic alopecia or female pattern hair loss in women, can lead to thinning hair and eventual hair loss. Research has shown that Saw palmetto works by inhibiting the enzyme 5-alpha-reductase, which converts testosterone to DHT. By reducing DHT levels in the scalp, Saw Palmetto may help slow down or prevent the miniaturization of hair follicles and potentially promote hair growth. Please see below reference to relevant scientific studies:

1) Evron E, Juhasz M, Babadjouni A, Mesinkovska NA. Natural Hair Supplement: Friend or Foe? Saw Palmetto, a Systematic Review in Alopecia. Skin Appendage Disord. 2020;6(6):329-337. doi:10.1159/000509905

Pine bark extract is derived from the bark of the maritime pine tree (Pinus pinaster). It is a potent antioxidant and is known for its various health benefits due to its high content of procyanidins, flavonoids, and other bioactive compounds. As a powerful antioxidant that can help neutralize free radicals and reduce oxidative stress it is beneficial for maintaining a healthy scalp environment and supporting hair follicles. Research has shown that it can also improve blood flow to the scalp and ensure the delivery of essential nutrients to the hair follicles. One study found that it is particularly effective in reducing hair loss in postmenopausal women. Please see below reference to relevant scientific studies:

1) Cai C, Zeng B, Lin L, et al. An oral French maritime pine bark extract improves hair density in menopausal women: A randomized, placebo-controlled, double blind intervention study. Health Sci Rep. 2023;6(1):e1045. Published 2023 Jan 6. doi:10.1002/hsr2.1045
2) Her Y, Lee TK, Sim H, et al. Pinus thunbergii bark extract rich in flavonoids promotes hair growth in dorsal skin by regulating inflammatory cytokines and increasing growth factors in mice. Mol Med Rep. 2022;25(3):100. doi:10.3892/mmr.2022.12616

Spirulina platensis is a blue-green algae that is rich in nutrients, including vitamins, minerals, proteins, and antioxidants all of which are essential for hair health. It is a complete protein source, meaning it contains all essential amino acids required for building and maintaining hair and hair follicles proteins like keratin and collagen. Spirulina is rich in antioxidants, such as phycocyanin and beta-carotene for which studies have shown that can help protect hair follicles from oxidative stress and damage caused by free radicals. Please see below reference to relevant scientific studies:

1) Dranseikienė D, Balčiūnaitė-Murzienė G, Karosienė J, et al. Cyano-Phycocyanin: Mechanisms of Action on Human Skin and Future Perspectives in Medicine. Plants (Basel). 2022;11(9):1249. Published 2022 May 5. doi:10.3390/plants11091249